In order to enhance the rehabilitation effect of intervention APP for autism spectrum disorder (ASD) children, and shed reasonable and effective light on the designers, this paper proposed an interface color matching evaluation method for ASD children intervention APP based on the system of PCCS (practical color coordinate system) color. Firstly, the literature analysis and focus group methods were used to construct the interface color matching evaluation system of ASD children intervention APP based on the PCCS color system. Secondly, the AHP method was used to obtain the weight of each evaluation index. Then eight interface color design schemes were selected based on the PCCS color system, experts were invited to offer their scores, and the initial judgment matrix was obtained. Then the ranking results of each scheme were obtained through the TOPSIS method. Finally, the results were analyzed. The results showed that ASD children were more likely to recognize green, blue, and other cool colors, as well as colors with higher lightness and purity. In the PCCS tonal figure, ASD children would prefer gentle tone, light color tone, the collocations of adjacent colors and complementary colors. In the interface color design, the color collocation should  be livelier, clear, harmonious, and stable. The evaluation method was applied to the evaluation of interface color matching experiments for intervention APP, and could boost the scientificity and objectivity in the process of design evaluation, and provide a reference for designers to make decisions, thus advancing the development of intervention APP for ASD children.